Andrea Dietrich

Researcher

E-mailadres: a.dietrich@accare.nl
Position: Researcher

Andrea Dietrich is a psychologist and senior researcher at Accare. Andrea is also associated with the University Medical Centre Groningen.

Biography

In her research, Andrea focuses primarily on the causes of tic disorders, ADHD and behavioural problems. She has a strong interest in exploring cognitive factors. Andrea was also European coordinator of the worldwide TIC Genetics study identifying the genes responsible for tics. She is interested in the interplay between genes and environmental factors, such as pregnancy complications or stress. In her clinically oriented research, she concentrates on the predictors of successful treatment, particularly the role of child characteristics, parents, and the family and social environment. She is also interested in improving the quality of life of children with tics and in the role of lifestyle factors in mental health.

Research studies
Publications

Research studies

Tic Genetics

Status: Analysis

The aim of this major international study is to discover the genes that cause Gilles de la Tourette syndrome and other tic disorders.

Aggressotype

Status: Analysis

The Aggressotype research study is a large-scale international study of the causes of various types of aggressive behaviour.

EMTICS

Status: Analysis

European Multicentre Tics in Children Study (EMTICS) is the first large-scale and long-term study of the role played by genes, inflammation processes and...

MASK

Status: Completed

This research study examines the efficacy of methylphenidate following more than two years of use.

TRAILS

Status: Analysis

TRAILS is a large-scale, longitudinal Dutch research study of the mental, social and physical development of over 2,500 adolescents progressing towards...

TS-Eurotrain

Status: Completed

The aim of this study was to investigate the role ADHD in children with tic disorders.

Methylphenidate: trial of discontinuation

Status: Searching participants

We are investigating if a trial of discontinuation is a good way of evaluating if medication is still necessary.

Predictors of treatment success

Status: Analysis

In this research study we have studied what the role is of family, parent, child and environmental factors in treatment success in child- and adolescent...

MATRICS

Status: Completed

Project which investigates the (neuro)biological mechanisms, genetics and potential novel treatment possibilities regarding aggression, behavioral problems...

NeuroIMAGE

Status: Analysis

NeuroIMAGE is an NWO-funded, Dutch follow-up study of the IMAGE project, which is a multi-site, international cohort study set up to investigate the genetics...

VANTASTIC

Status: Analysis

Do vitamins and minerals help to become less irritable?

DREAMS

Status: New

DREAMS is a collaboration between the four large, academic institutions for child and adolescent psychiatry in the Netherlands: Accare, Curium , Karakter and...

Problematic handling of emotions in youth with ADHD

Status: Analysis

Bij dit onderzoek moesten jongeren met en zonder ADHD emoties op foto's herkennen. Terwijl ze dit deden lagen ze onder een scanner en werd onderzocht welke...

Genetics and brain function of children with ADHD

Status: Analysis

We aimed to investigate possible associations between polygenic risk score for ADHD (PRS-ADHD) and core symptoms of ADHD, and subsequently explore how...

Genetics of aggression and brain white matter structure

Status: Completed

Investigation of the genetics of aggression-related phenotypes, using data from NeuroIMAGE.

Genetics of aggression and brain white matter structure

Status: Analysis

In this research study we hope to learn more about the development of antisocial and aggressive behaviour.

SCODA

Status: Searching participants

Youth with behavioural problems (also referred to as disruptive behaviour) often experience difficulties in their interactions with other people. We think...

SCASS

Status: Searching participants

In this study we investigate how social information is processed in the brain of adolescents with and without ASD.

Bounce Back

Status: New

Study on risk and resilience, differences in coping strategies, quality of life and stigma. We will study this in children and adolescents with Tourette...

More research studies

Publications

Genome-wide association study meta-analysis of 9,619 cases with tic disorders

Published on date

October 2024

Published in

Biological Psychiatry

Parent Training for Disruptive Behaviors in Referred Children with Autism Spectrum Disorder: A Randomized Controlled Trial

Published on date

September 2024

Published in

Journal of Autism and Developmental Disorders

Patterns of Mental Disorders in a Large Child Psychiatric Sample (N = 65,363): A DREAMS Study

Published on date

August 2024

Published in

JAACAP Open

Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group

Published on date

August 2024

Published in

The Lancet. Psychiatrie.

Long-Term Effectiveness of Off-Label Risperidone Treatment in Children and Adolescents: A Randomized, Placebo-Controlled Discontinuation Study

Published on date

August 2024

Published in

Journal of Child & Adolescent Psychopharmacology

ADHD medication adherence reduces risk of committing minor offenses in adolescents

Published on date

May 2024

Published in

Journal of Child Psychology and Psychiatry, and applied sciences

Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD

Published on date

December 2023

Published in

Nature Communications

Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors

Published on date

November 2023

Published in

Neuroimage. Clinical

Age-related brain deviations and aggression

Published on date

July 2023

Published in

Psychological medicine

Shared genetic etiology between ADHD, task-related behavioral measures and brain activation during response inhibition in a youth ADHD case-control study

Published on date

June 2023

Published in

European Archives of Psychiatry and Clinical Neuroscience

Adherence to Clinical Guidelines for Dose Finding and Monitoring Methylphenidate Use: A Medical Record Audit in Child and Adolescent Mental Health Care and Pediatric Settings

Published on date

June 2023

Published in

Journal of Child and Adolescent Psychopharmacology

Hair Cortisol and Perceived Stress-Predictors for the Onset of Tics? A European Longitudinal Study on High-Risk Children

Published on date

May 2023

Published in

Biomedicines

Moderating Role of Depression on the Association of Tic Severity With Functional Impairment in Children

Published on date

April 2023

Published in

Pediatric Neurology

Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Published on date

February 2023

Published in

Translational Psychiatry

Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome

Published on date

February 2023

Published in

Biological psychiatry

Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children

Published on date

December 2022

Published in

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the official publication of the international society of psychiatric genetics

Amygdala reactivity and ventromedial prefrontal cortex coupling in the processing of emotional face stimuli in attention-deficit/hyperactivity disorder

Published on date

December 2022

Published in

European Child & Adolescent Psychiatry

Clinicians' Adherence to Guidelines When Initiating Methylphenidate Treatment

Published on date

November 2022

Published in

Journal of Child and Adolescent Psychopharmacology

Factors Related to Perceived Stigma in Parents of Children and Adolescents in Outpatient Mental Healthcare

Published on date

October 2022

Published in

International Journal of Environmental Research and Public Health

Emotion recognition profiles in clusters of youth based on levels of callous-unemotional traits and reactive and proactive aggression

Published on date

September 2022

Published in

European Child & Adolescent Psychiatry

Polygenic risk scores for antisocial behavior in relation to amygdala morphology across an attention deficit hyperactivity disorder case-control sample with and without disruptive behavior

Published on date

September 2022

Published in

European Neuropsychopharmacology : The journal of the European College of Neuropsychopharmacology

Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Published on date

August 2022

Published in

Frontiers in Psychiatry

Age-related brain deviations and aggression

Published on date

April 2022

Published in

Psychological Medicine

Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study

Published on date

February 2022

Published in

Neurology

First do no harm: use off-label antipsychotic medication in children and adolescents with great caution

Published on date

January 2022

Published in

European Child & Adolescent Psychiatry

Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence

Published on date

November 2021

Published in

Neuroimage

Mycoplasma pneumoniae IgG positivity is associated with tic severity in chronic tic disorders

Published on date

October 2021

Published in

Brain, behaviour and immunity

Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree

Published on date

September 2021

Published in

Molecular Psychiatry

Investigation of gene-environment interactions in relation to tic severity

Published on date

August 2021

Published in

Journal of Neural Transmission (Vienna)

Early-Life Environmental and Child Factors Associated with the Presence of Disruptive Behaviors in Seven-Year-Old Children with Autistic Traits in the Avon Longitudinal Study of Parents and Children

Published on date

1 July 2021

Published in

Journal of Autism and developmental disorders

Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder

Published on date

July 2021

Published in

Scientific Reports

Parental rejection in early adolescence predicts a persistent ADHD symptom trajectory across adolescence

Nederlandse samenvatting.

Published on date

July 2021

Published in

European Child & Adolescent Psychiatry

Clinical precursors of tics: an EMTICS study

Published on date

25 June 2021

Published in

Journal of Child Psychology and Psychiatry, and allied disciplines

Tics ontstaan meestal tussen de 3 en 6 jaar. Van andere aandoeningen zoals autisme of schizofrenie is bekend dat er al vroege tekenen zijn van ‘anders zijn’. Nog voordat de eerste duidelijke symptomen van de aandoening optreden. In dit onderzoek vroegen we ons af of kinderen die tics ontwikkelen al op vroege leeftijd ‘anders’ zijn. Dit is nog nooit eerder onderzocht bij tics.

Amygdala reactivity and ventromedial prefrontal cortex coupling in the processing of emotional face stimuli in attention-deficit/hyperactivity disorder

Published on date

1 June 2021

Published in

European Child & Adolescent Psychiatry

Impaired response inhibition during a stop-signal task in children with Tourette syndrome is related to ADHD symptoms: A functional magnetic resonance imaging study

Published on date

June 2021

Published in

The World Journal of Biological Psychiatry

Tics zijn plotseling en snel. Dit zou er wel eens toe kunnen leiden dat kinderen met tics minder goed gedrag kunnen afremmen. Dit is een belangrijke vaardigheid om ons gedrag te reguleren. Kinderen met ADHD hebben ook vaak moeite met het afremmen van gedrag en zijn impulsief. ADHD komt vaak voor bij kinderen met tics. We hebben daarom onderzocht of het afremmen van gedrag te maken heeft met...

Tic disorders in children and adolescents: does the clinical presentation differ in males and females? A report by the EMTICS group

Published on date

May 2021

Published in

European Child & Adolescent Psychiatry

Introductie, geen titel

Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families

Published on date

9 April 2021

Published in

Molecular Psychiatry

Tics zijn in hoge mate erfelijk en komen vaak binnen families voor. Onderzoek naar families met meerdere familieleden met tics (ook “multiplex families” genoemd) geeft belangrijke aanwijzingen over welke genen een rol spelen bij tics.

Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study

Published on date

April 2021

Published in

European Child & Adolescent Psychiatry

Introductie, geen titel

Effects of methylphenidate on executive functioning in children and adolescents with ADHD after long-term use: a randomized, placebo-controlled discontinuation study

Published on date

28 March 2021

Published in

Journal of Child Psychology & Psychiatry, and allied disciplines

Methylfenidaat (beter bekend als Ritalin of Concerta) kan de informatieverwerking (zoals aandacht en geheugen) van kinderen en jongeren met ADHD verbeteren. Het is nog onduidelijk of methylfenidaat na lang gebruik (meer dan 2 jaar) hierop nog steeds een effect heeft.

Association of Group A Streptococcus Exposure and Exacerbations of Chronic Tic Disorders: A Multinational Prospective Cohort Study

Published on date

March 2021

Published in

Neurology

Introductie, geen titel

Reward and Punishment Sensitivity are Associated with Cross-disorder Traits

Published on date

February 2021

Published in

Psychiatry research

Yale Global Tic Severity Scale (YGTSS): Psychometric Quality of the Gold Standard for Tic Assessment Based on the Large-Scale EMTICS Study

Published on date

February 2021

Published in

Frontiers in psychiatry

Guideline Adherence of Monitoring Antipsychotic Use for Nonpsychotic Indications in Children and Adolescents: A Patient Record Review

Published on date

February 2021

Published in

Journal of clinical psychopharmacology

Introductie, geen titel

Synaptic processes and immune-related pathways implicated in Tourette syndrome

Published on date

January 2021

Published in

Translational Psychiatry

Hair cortisol-a stress marker in children and adolescents with chronic tic disorders? A large European cross-sectional study

Published on date

January 2021

Published in

European Child & Adolescent Psychiatry

Introductie, geen titel

Prescribing antipsychotics in child and adolescent psychiatry: guideline adherence

Published on date

1 December 2020

Published in

European Child & Adolescent Psychiatry

Subgrouping children and adolescents with disruptive behaviors: symptom profiles and the role of callous-unemotional traits

Published on date

4 November 2020

Published in

European Child and Adolescent Psychiatry

The Premonitory Urge for Tics Scale in a large sample of children and adolescents: psychometric properties in a developmental context. An EMTICS study

Published on date

October 2020

Published in

European Child and Adolescent Psychiatry

In dit onderzoek keken we naar zogenaamde ‘tic-alerts’. Tic-alerts, ook tic-alarmen genoemd, zijn lichamelijke prikkelingen die vaak voorafgaan aan een tic. Deze ‘tic-alerts’ spelen een belangrijke rol bij de gedragsbehandeling van tics. Tot nu toe dachten onderzoekers dat deze ‘tic-alerts’ pas rond het tiende jaar duidelijk aanwezig waren. We onderzochten de psychometrische kwaliteiten van de...

Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Published on date

13 August 2020

Published in

European Child & Adolescent Psychiatry

Specific cortical and subcortical alterations for reactive and proactive aggression in children and adolescents with disruptive behavior

Published on date

11 July 2020

Published in

NeuroImage Clinical

Anti-dopamine D2 receptor antibodies in chronic tic disorders

Published on date

9 July 2020

Published in

Developmental Medicine and Child Neurology

The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces

Published on date

6 July 2020

Published in

Psychological medicine

A graph theory study of resting-state functional connectivity in children with Tourette syndrome

Published on date

May 2020

Published in

Cortex

Hersengebieden communiceren met elkaar om informatie uit te wisselen. Bij het opgroeien veranderen verbindingen tussen bepaalde hersengebieden. Ze worden korter of langer, of dikker of dunner en meestal efficiënter. Dit kan worden gemeten middels MRI onderzoek (hersenscan) in rust. Er zijn ideeën dat er bij kinderen met tics sprake zou kunnen zijn van verbindingen die niet goed met elkaar...

Praktijkondersteuner jeugd bij de huisarts: betere zorg én geld besparen!

Published on date

30 April 2020

Published in

Tijdschrift voor Orthopedagogiek, uitgave 2 - 2020, jaargang 59, 30 april 2020, pagina 40

Serra, M.

Aggression based genome-wide, glutamatergic, dopaminergic and neuroendocrine polygenic risk scores predict callous-unemotional traits

Published on date

April 2020

Published in

Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology

Executive functioning and emotion recognition in youth with oppositional defiant disorder and/or conduct disorder

Published on date

April 2020

Published in

The World Journal of Biological Psychiatry

Gedragsproblemen kunnen ontstaan door de manier waarop de hersenen werken. We weten alleen nog niet goed welke hersenfuncties een rol spelen. Daarom onderzochten wij verschillende functies in jeugd met gedragsproblemen en jeugd zonder gedragsproblemen. Ook keken we naar verschillen tussen opstandig gedrag (ODD) en normoverschrijdend gedrag (CD).

Executive function in children with Tourette syndrome and attention-deficit/hyperactivity disorder: Cross-disorder or unique impairments?

Published on date

1 March 2020

Published in

Cortex

Kinderen met ADHD hebben vaak informatieverwerkingsproblemen. Zo doen ze het dikwijls minder goed op taken die cognitieve controle en werkgeheugen vereisen. Vaak reageren ze impulsief en doen dingen zonder nadenken. ADHD komt ook vaak voor bij kinderen met tics. In hoeverre kinderen met tics ook last hebben van informatieverwerkingsproblemen is onduidelijk. Daarom vergeleken we drie groepen...

Prescribing antipsychotics in child and adolescent psychiatry: guideline adherence

Published on date

12 February 2020

Published in

European Child & Adolescent Psychiatry

Aggression based genome-wide, glutamatergic, dopaminergic and neuroendocrine polygenic risk scores predict callous-unemotional traits

Published on date

9 January 2020

Published in

Neuropsychopharmacology

Effects of Discontinuing Methylphenidate on Strengths and Difficulties, Quality of Life and Parenting Stress

Published on date

24 December 2019

Published in

Journal of child and adolescent psychopharmacology

Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior

Published on date

December 2019

Published in

Cortex; a journal devoted to the study of the nervous system and behaviour

Serra, M.

Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder

Published on date

30 October 2019

Gepubliceerd

ADHD symptoms across adolescence: the role of the family and school climate and the DRD4 and 5-HTTLPR genotype

Published on date

18 October 2019

Published in

European child & adolescent psychiatry

Brinksma DM, Dietrich A, de Bildt A, Buitelaar JK, van den Hoofdakker BJ, Hoekstra PJ, Hartman CA

Factors related to parental pre-treatment motivation in outpatient child and adolescent mental health care

Published on date

24 September 2019

Published in

European Child & Adolescent Psychiatry

Introductie, geen titel

Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior

Published on date

19 September 2019

Published in

Cortex; a journal devoted to the study of the nervous system and behavior

Interplay between genome-wide implicated genetic variants and environmental factors related to childhood antisocial behavior in the UK ALSPAC cohort

Published on date

September 2019

Published in

European Archives of Psychiatry and Clinical Neuroscience

Antibodies to neuronal surface proteins in Tourette Syndrome: Lack of evidence in a European paediatric cohort

Published on date

16 August 2019

Published in

Brain Behavaviour and Immunity

Continued Benefits of Methylphenidate in ADHD After 2 Years in Clinical Practice: A Randomized Placebo-Controlled Discontinuation Study

Published on date

21 May 2019

Published in

The American Journal of Psychiatry

Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

Published on date

1 March 2019

Published in

American Journal of Psychiatry

Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort

Published on date

15 February 2019

Published in

Biological Psychiatry

European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

Published on date

January 2019

Published in

European Child & Adolescent Psychiatry

ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes

Published on date

October 2018

Published in

Journal of Abnormal Child Psychology

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Published on date

25 September 2018

Published in

Cell Reports

Wang S, Mandell JD, Kumar Y, Sun N, Morris MT, Arbelaez J, Nasello C, Dong S, Duhn C, Zhao X, Yang Z, Padmanabhuni SS, Yu D, King RA, Dietrich A, Khalifa N, Dahl N, Huang AY, Neale BM, Coppola G, Mathews CA, Scharf JM; Tourette International Collaborative Genetics Study (TIC Genetics); Tourette Syndrome Genetics Southern and Eastern Europe Initiative (TSGENESEE); Tourette Association of America...

Analysis of shared heritability in common disorders of the brain

Published on date

22 June 2018

Published in

Science

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva...

Pregnancy risk factors in relation to oppositional-defiant and conduct disorder symptoms in the Avon Longitudinal Study of Parents and Children

Published on date

June 2018

Published in

Journal of Psychiatric Research

Ruisch IH, Buitelaar JK, Glennon JC, Hoekstra PJ, Dietrich A.

Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach

Published on date

April 2018

Published in

European Archives of Psychiatry and Clinical Neuroscience

Abdulkadir M, Londono D, Gordon D, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, Elzerman L, Fremer C, Fründt O, Garcia-Delgar B, Gilbert DL, Grice DE, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Jakubovski E, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy TL, Plessen KJ, Roessner V,...