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Tic Genetics

Which genes cause tic disorders?

Status
Analysis

Tics are known to be largely genetically determined. However, the genes that cause tics have not yet been identified. The aim of this major international study is to discover the genes that cause Gilles de la Tourette syndrome and other tic disorders.

Background

TIC Genetics stands for Tourette International Collaborative Genetics. The purpose of this major international study is to discover the genes that cause Gilles de la Tourette syndrome and other tic disorders. Tic disorders - and associated issues such as attention problems and compulsive disorders - are becoming more common within families. It is not yet clear why one family member has tics while other family members do not. 

The research study

Participants completed a single questionnaire. This included questions about tics, compulsions and other health issues, and about their birth. Participants also visited us once, to take a blood sample. We have collected data from around 3.000 people between 2018 en 2023. 

Collaboration

TIC Genetics is a major international study, which started in 2011. Over 20 clinical sites in Europe, the United States and South Korea are participating in TIC Genetics. The project is funded by the National Institute of Mental Health (NIMH) in the United States.

Read more on the Tic Genetics research website Deze link opent in een nieuw venster

Publications

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Published on date

25 September 2018

Published in

Cell Reports

Wang S, Mandell JD, Kumar Y, Sun N, Morris MT, Arbelaez J, Nasello C, Dong S, Duhn C, Zhao X, Yang Z, Padmanabhuni SS, Yu D, King RA, Dietrich A, Khalifa N, Dahl N, Huang AY, Neale BM, Coppola G, Mathews CA, Scharf JM; Tourette International Collaborative Genetics Study (TIC Genetics); Tourette Syndrome Genetics Southern and Eastern Europe Initiative (TSGENESEE); Tourette Association of America...

Analysis of shared heritability in common disorders of the brain

Published on date

22 June 2018

Published in

Science

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y,  Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva...

Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach

Published on date

April 2018

Published in

European Archives of Psychiatry and Clinical Neuroscience

Abdulkadir M, Londono D, Gordon D, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, Elzerman L, Fremer C, Fründt O, Garcia-Delgar B, Gilbert DL, Grice DE, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Jakubovski E, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy TL, Plessen KJ, Roessner V,...